USP18 – a multifunctional component in the interferon response
Identifieur interne : 000683 ( Main/Exploration ); précédent : 000682; suivant : 000684USP18 – a multifunctional component in the interferon response
Auteurs : Anja Basters [Suisse] ; Klaus-Peter Knobeloch [Allemagne] ; Günter Fritz [Allemagne]Source :
- Bioscience Reports [ 0144-8463 ] ; 2018.
Abstract
Ubiquitin-specific proteases (USPs) represent the largest family of deubiquitinating enzymes (DUB). These proteases cleave the isopeptide bond between ubiquitin and a lysine residue of a ubiquitin-modified protein. USP18 is a special member of the USP family as it only deconjugates the ubiquitin-like protein ISG15 (interferon-stimulated gene (ISG) 15) from target proteins but is not active towards ubiquitin. Independent of its protease activity, USP18 functions as a major negative regulator of the type I interferon response showing that USP18 is – at least – a bifunctional protein. In this review, we summarise our current knowledge of protease-dependent and -independent functions of USP18 and discuss the structural basis of its dual activity.
Url:
DOI: 10.1042/BSR20180250
PubMed: 30126853
PubMed Central: 6240716
Affiliations:
- Allemagne, Suisse
- Bade-Wurtemberg, District de Fribourg-en-Brisgau, District de Stuttgart
- Fribourg-en-Brisgau, Stuttgart
- Université de Hohenheim
Links toward previous steps (curation, corpus...)
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Le document en format XML
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last="Basters">Anja Basters</name><affiliation wicri:level="1"><nlm:aff id="A1">Friedrich Miescher Institute for Biomedical Research, Quantitative Biology, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Friedrich Miescher Institute for Biomedical Research, Quantitative Biology, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Knobeloch, Klaus Peter" sort="Knobeloch, Klaus Peter" uniqKey="Knobeloch K" first="Klaus-Peter" last="Knobeloch">Klaus-Peter Knobeloch</name><affiliation wicri:level="3"><nlm:aff id="A2">Faculty of Medicine, Institute of Neuropathology, University of Freiburg, Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Faculty of Medicine, Institute of Neuropathology, University of Freiburg, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de 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Hohenheim, Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName><orgName type="university">Université de Hohenheim</orgName></affiliation></author></analytic><series><title level="j">Bioscience Reports</title><idno type="ISSN">0144-8463</idno><idno type="eISSN">1573-4935</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ubiquitin-specific proteases (USPs) represent the largest family of deubiquitinating enzymes (DUB). 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Duarte</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>Bade-Wurtemberg</li><li>District de Fribourg-en-Brisgau</li><li>District de Stuttgart</li></region><settlement><li>Fribourg-en-Brisgau</li><li>Stuttgart</li></settlement><orgName><li>Université de Hohenheim</li></orgName></list><tree><country name="Suisse"><noRegion><name sortKey="Basters, Anja" sort="Basters, Anja" uniqKey="Basters A" first="Anja" last="Basters">Anja Basters</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Knobeloch, Klaus Peter" sort="Knobeloch, Klaus Peter" uniqKey="Knobeloch K" first="Klaus-Peter" last="Knobeloch">Klaus-Peter Knobeloch</name></region><name sortKey="Fritz, Gunter" sort="Fritz, Gunter" uniqKey="Fritz G" first="Günter" last="Fritz">Günter Fritz</name><name sortKey="Fritz, Gunter" sort="Fritz, Gunter" uniqKey="Fritz G" first="Günter" last="Fritz">Günter Fritz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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